Dying with dignity– free from machines

Prahlad K Sethi 1 and Nitin K Sethi, MD2

 

1 Department Neurology, Sir Ganga Ram Hospital, New Delhi, India

2 Department of Neurology, New York-Presbyterian Hospital, Weill Cornell Medical Center, New York, NY (U.S.A.)

 

 

 

In recent years, rapid advances in medicine and critical care have produced a plethora of procedures (endotracheal intubation, central venous lines placement, tracheostomy) and medical devices (mechanical ventilators, infusion pumps, dialysis machines) to support and sustain life. For physicians, caregivers and most importantly patients it is more important than ever before to make wise decisions about life-sustaining medical treatments. End-of-life (EOL) decision making process though is complex and involves difficult decisions for all concerned (patients, caregivers, physicians and nurses).

 

The Hippocratic Oath requires a newly minted physician to swear by the healing gods of Apollo, Asclepius, Hygieia and Panacea that he/she shall withhold certain ethical standards. The classical version of the oath hints at applying for the benefit of the sick, all measures that are required/available. Physicians hence by virtue of their training are programmed to support life by all measures at their disposal. The modern version of the oath advices physician to do the above while avoiding the twin traps of overtreatment and therapeutic nihilism. Unfortunately in medical schools across India, physicians in training are not taught how to avoid these two traps. When does a physician say no more? How does he communicate the futility of further medical treatment to the patient and the caregiver/family? There are no simple answers to the above questions. Disagreement about the goals of treatment between patient, family members and physician providers leads to misunderstanding and distrust.

 

 

 

 

 

 

For physicians it is important to treat the patient and family members humanely as EOL approaches. This begins with a clear explanation of the disease process and prognosis to the patient and his family. What is the life expectancy, what can the patient and family expect as the disease progresses? Will the various procedures and devices available to support and sustain life, have a meaningful outcome in the long term. For a physician it is important to prognosticate on not just life expectancy but also on the quality of life after these procedures/ interventions. Will the patient be able to talk, eat, walk independently or will he be bed bound, dependent on a dialysis machine, with a tracheostomy and feeding tube? All these questions no matter how difficult, need to be addressed with the patient and his family.  In the movie The Wrath of Khan (1982), Spock in his usual logical way says “the needs of the many outweigh the needs of the few” (“or the one”). Doctors have a moral obligation to not just the patient in front of them but also to the larger society. They have to wrestle with questions whether the medical resources currently devoted to their patient could be better utilized for care of other potentially salvageable patients. But a doctor should never forget that in the  patient or family member’s eye “the needs of the one may outweigh the needs of the many”.

 

 

 

 

 

 

 

 

 

 

 

 

Case-1 A-85-year old lady, diagnosed with a brain tumor (glioma)  3-4 months back and on antiepileptics, presented to the casualty with recurrent seizures. On presentation, she had a Glasgow Coma Scale (GCS) score of 3. She was loaded with IV antiepileptics. Though she warranted admission to the intensive care unit, she was admitted to the neurology floor respecting the wishes of her family who declined intubation and mechanical ventilation. Surprisingly her sensorium improved the next day and she started to communicate and accept orally. She though again declined. Respecting her and the family’s wishes, palliative care and comfort care measures were instituted. She went into a sudden cardiorespiratory arrest on day 3 and passed away peacefully with her family by her side.

 

Case –2: A-87-year old lady, known case of hypertension with coronary artery disease (CAD) status-post coronary artery bypass grafting (CABG) and angioplasty came to our casualty with sudden loss of consciousness. On examination, she was found to have left-sided hemiparesis with poor GCS score. CT head revealed sulcal effacement with early developing hypodensity in large area of right middle cerebral artery (MCA) territory. MRI brain confirmed large right hemispheric infarct and left posterior cerebral artery (PCA) territory infarct. After the poor prognosis was explained to the relatives, they decided to pursue palliative care. Do not intubate (DNI) and do not resuscitate (DNR) orders were signed. Patient went into cardiac arrest and passed away.

 

Case-3: A-86-year old bed bound male, known case of advanced Parkinson’s plus disease with dementia, presented with history of decreased oral intake, difficulty breathing, fever and altered sensorium for 2 days. He was encephalopathic with bilateral aspiration pneumonia and sepsis. After the poor prognosis was explained to family members, they elected against intubation and mechanical ventilation. He was managed on the neurology floor with oxygen, non-invasive mechanical ventilation (BiPAP), nebulization, chest physiotherapy with periodic suctioning along with IV antibiotics and other supportive care treatments. Due attention was given to hydration and nutrition status. Five days later, he developed sudden cardiorespiratory arrest and passed away.

 

Case-4: A- 61-year old lady, having multiple co morbidities (old stroke with right sided hemiparesis, diabetes, hypertension, interstitial lung disease, old pulmonary tuberculosis, chronic liver disease with anemia) presented with complaints of diarrhea, fever and breathlessness for 2 days. She was found to have bilateral pneumonia with hypoxemia. After the poor outcome was discussed with relatives in terms of possibility of difficulty weaning off from ventilatory support, they elective to pursue comfort care measures. Patient was managed with IV antibiotics, antihypertensive, antidiabetic and other supportive treatments along with non-invasive (BiPAP) ventilation. She passed away 6 days after admission with her family by her bedside.

 

 

 

Dying with dignity

 

On March 7th, 2011, the Law Commission of India, Ministry of Law and Justice in a landmark judgment recommended to the Government of India that terminally ill patients should be allowed to end their lives. By passing this judgment, India joined a small select group of nations that allow euthanasia in some form or other. This judgment has led to a vigorous debate in the media about euthanasia and the right to die. Just what is euthanasia and what is the difference between active and passive forms of euthanasia? The word euthanasia is derived from Greek: eu ‘well’ + thanatos ‘death’. The Oxford dictionary defines euthanasia as the practice of killing without pain a person who is suffering from a disease that cannot be cured1. The Stedman’s medical dictionary gives a more comprehensive definition and defines it as the act or practice of ending the life of an individual suffering from a terminal illness or an incurable condition, as by lethal injection or the suspension of extraordinary medical treatment2.

Active euthanasia (as for example mercy killing via a lethal injection or by giving an overdose of pain killers and sleeping pills) is currently illegal in almost all countries of the world. In most countries a physician who assists in active euthanasia can be prosecuted, lose his license to practice medicine and can even be jailed. The patient requesting active euthanasia can also be prosecuted. Put in another way the law as it stands now condemns a physician for actively killing someone (even though the patient requests it) but does not condemn a physician for failing to save a terminally ill patient’s life (aka active euthanasia is illegal but not passive euthanasia). Netherlands and Switzerland are two countries where active euthanasia is practiced openly though the medical, legal and social implications remain active topics for both professional and public debate. The courts in these two countries have allowed physicians to practice active euthanasia under certain strict conditions. In these countries too physician assisted euthanasia (the physician prescribes the lethal medication but it is the patient who self-administers the lethal medication) is more widely accepted (both by the public at large as well as ethically and morally by the physician community) than active euthanasia (physician administers the lethal injection himself). In Netherlands the following guidelines if followed strictly have traditionally protected physicians from prosecution: the patient’s wish to die must be expressed clearly and repeatedly, the patient’s decision must be well informed and voluntary, the patient must be suffering intolerably with no hope for relief however the patient does NOT have to be terminally ill (mental suffering is acceptable as a reason for performing assisted suicide and euthanasia in a patient who may be physically healthy), the physician must consult with at least one other physician, the physician must notify the local coroner that death resulting from unnatural causes has occurred 3.

There is an ever increasing demand for the “right to die with dignity”. In an essay in the International Herald Tribune the right to die was defined as follows: “every person shall have the right to die with dignity; this right shall include the right to choose the time of one’s death and to receive medical and pharmaceutical assistance to die painlessly. No physician, nurse or pharmacist shall be held criminally or civilly liable for assisting a person in the free exercise of this right.” A fundamental thought underlying the right to die is the belief that one’s body and one’s life are one’s own, to dispose of as one sees fit. So theoretically if one wants to commit suicide one should have the freedom/ right to do so. Opponents of the right to die point out that legalizing the right to die may lead to irrational suicides. Different religions have different thoughts of view when it comes to the right to die. Hinduism in fact accepts the right to die for those suffering from terminal illnesses allowing death through the non-violent practices of fasting to death (Prayopavesa). Some Jains practice Santhara by which they seek voluntary death through fasting. Since the decision to practice Santhara is taken while one possesses a sound mind and is aware of the intent it cannot be equated to suicide which is usually carried out in haste when a person is in the midst of depression they point out.

 

 

A form of passive euthanasia and dying with dignity by withholding extraordinary life supporting measures (such as the decision to intubate and mechanically ventilate a terminally ill patient) is already routinely practiced in critical care units across India on a daily basis. In our experience once the hopelessness of the medical situation and the gravity of the illness is explained to the patient and the relatives, they comprehend and at times request discharge from the hospital so that the patient can take his last breath at home surrounded by family and friends. It is only when disagreements about the need, timing or mode of termination of care arise among family members or when a conflict of interest is perceived by the family members with respect to the treating physicians (‘they want him to die so that they can have the bed/ ventilator’) that these cases reach the attention of the media and the public at large such as in the case of Aruna Shanbaug.

 

The right to die with dignity is a fundamental right of every person. The terms of this dignified death may vary from patient to patient. For some it may be dying at home surrounded by close family and friends, others in the hospital might wish to avoid the “trauma” of intubation and mechanical ventilation but continue with intravenous hydration and other comfort care measures, still others may wish for everything to be done. Doctors should explore patient and family’s wishes on these issues and respect them.

 

 

 

 

In the words of Frank Sinatra from his famous song “My way”…

 

“And now, the end is near
And so I face the final curtain
My friend, I’ll say it clear
I’ll state my case, of which I’m certain

I’ve lived a life that’s full
I’ve traveled each and every highway
But more, much more than this
I did it my way”

 

Men like “Tiger” Nawab Pataudi and Dara Singh not only lived their lives “their way” but also died on their own terms-with dignity.

 

Dying can be a peaceful event or a great agony when it is inappropriately sustained by life support.” –

Roger Bone

 

 

 

References

 

  1. Oxford dictionary online at http://oxforddictionaries.com
  2. Stedman’s Online Medical Dictionary at http://www.stedmans.com
  3. http://www.libraryindex.com/pages/573/Euthanasia-Assisted-Suicide

 

Making Boxing Safer

Boxing as a sport is close to my heart. Boxing is also a sport with a high risk for traumatic brain injuries. Ringside physicians are entrusted with the health and safety of boxers and combatants of other contact sports such as MMA. The health and safety of boxers is something I am passionate about.

boxer-safety-final-edited

The Powerpoint presentation reflects some of my thoughts on how boxing can be made safer primarily targeted at referees. It talks about the importance of constant communication between ringside physicians and referees. The views and opinions expressed are entirely my own. They do not reflect the views of the New York State Athletic Commission or any other boxing governing body. I disclose that I work for the New York State Athletic Commission as a ringside physician.

 

Nitin K Sethi, MD

Localization in epilepsy-making the diagnosis

In this post I shall explain in simple terms how a diagnosis of epilepsy is made by neurologists. First to get a few terms clarified:

The terms “Seizure disorder” and “Epilepsy” are frequently used interchangeably. They both mean the same. The person who is diagnosed with “epilepsy” or “seizure disorder” has a condition which makes him/her prone to having multiple seizures in his lifetime. Another way to put this is a follows. If you are diagnosed with epilepsy, it means that more than likely you shall suffer seizures in your lifetime if you do not take anticonvulsant therapy (anti seizure medication).

Remember any of us can suffer a seizure but it does not mean we have epilepsy. Let me explain with the aid of an example. Think of a person who suffers a seizure because he drank too much or consumed an illicit drug such as cocaine. Now this person has certainly suffered a convulsion/seizure but he does not necessarily have epilepsy. This person has suffered a seizure provoked by an illicit drug. If this person does not consume excess alcohol again/ avoids illicit drug; he may never suffer another seizure in his lifetime. Contrast this with a patient who has epilepsy. The person who has epilepsy is predisposed to having seizures in his lifetime (he/she has an inherent predisposition to seizures-at times this inherent predisposition is due to genetic causes. Other times it may be on account of other causes such as a brain tumor, a vascular (blood vessel) malformation in the brain, a cyst in the brain, due to prior head trauma/injury, due to an old history of meningitis or encephalitis).

So how is the diagnosis of epilepsy made by neurologists. Well when a patient presents to us with a history of seizure; we first attempt to collaborate the history with additional history from the family (preferably someone who may have witnessed the convulsion). This is important because it helps us to distinguish a seizure from seizure mimics such as fall with loss of consciousness, fainting and other causes of confused behavior with or without loss of consciousness. So first and foremost the diagnosis of epilepsy is made based on a good history. As I sometimes tell my patients, I do not want to “miss” a diagnosis of epilepsy (as seizures are associated with falls, injury and sometimes can cause sudden death). At the same time, I do not want to “over-diagnose” someone with epilepsy (as patients usually have to take anticonvulsant drugs for a long time and these drugs do have side-effects). Herein lies the importance and value of good history taking.

Next come the tests which help to “confirm” the diagnosis of epilepsy. Two tests are commonly carried out. A MRI of the brain is usually carried out to rule out “secondary” causes of epilepsy such as brain tumor, cyst, vascular malformation of the brain, look for “scars” of prior head injury or infections. The second test which is carried out is an electroencephalogram (also called a EEG). This test is carried out to look at the brain waves and identify where in the brain (right Vs left side of brain, which part of the brain) is the “misfiring” coming from. The above two tests in conjunction with history help to confirm the diagnosis of epilepsy.

Nitin K Sethi, MD

Concussions and the risk of post-traumatic epilepsy

Concussions and the risk of post-traumatic epilepsy

 

A concussion is a complex pathophysiological process affecting the brain, induced by traumatic biomechanical forces. Immediately following a concussion, an athlete is usually advised physical and cognitive rest till post-concussion symptoms abate. The athlete then enters a stepwise return to play protocol. Premature return to play risks a second concussion, second impact syndrome, exacerbation and persistence of post-concussive symptoms.

 

Sports and Epilepsy

Sport is important not only in normal healthy populations, but also in persons with medical illness, physical or mental disabilities. Active participation in sports is beneficial physically and psychologically. The main concern in sports for persons with epilepsy is safety.

 

Why are people with epilepsy restricted from some sports?

 

Rationale is that the occurrence of an untimely seizure during certain sporting event has the potential for causing substantial injury and bodily harm both to the patient with epilepsy as well as fellow athletes and even spectators.

 

Example: if a person with epilepsy has a generalized convulsion or a complex partial seizure while skydiving: he shall not be able to deploy his parachute and a fatal accident can occur.

 

:a person with epilepsy taking part in an automobile racing event suffers a seizure while making a bend at speeds in excess of 100mph

 

:a person with epilepsy suffers a seizure while taking part in a swimming meet.

 

:a person with epilepsy suffers a seizure while bicycling

 

:a person with epilepsy suffers a seizure while horseback riding

 

:a person with epilepsy suffers a seizure while skiing down a steep hill

 

:even things more mundane such as having a seizure while running on a treadmill, while playing tennis, while jogging outside have the potential to cause bodily harm to the patient and others.

 

 

Why are people with epilepsy restricted from some sports?

 

Rationale is that repeated injury to the head (concussions) during some sports could potentially exacerbate seizures.

Example: a person with epilepsy who is indulging in contact sports such as boxing, karate, kick-boxing, muay thai boxing, American football, ice-hockey, wrestling, judo

 

But are these restrictions and fears actually based on scientific evidence or are they unfounded? Which sports are safe and which are not? Could indulgence in some sports make seizures potentially worse Vs. could some sports actually be beneficial for people with epilepsy (physically and psychologically)? Can vigorous physical exercise provoke seizures?

 

 

Exercise and seizures

 

One reason that people with epilepsy have been traditionally restricted from certain sports is the fear both in the patient and the treating physician that exercise especially aerobic exercise may exacerbate seizures. Some studies have shown an increase in interictal discharges during or after exercise. Most frequently these patients have generalized epilepsies. At least some frontal lobe and temporal lobe seizures are clearly precipitated or at times solely occur during exercise suggests that these are a form of reflex epilepsies. A number of physiologic mechanism by which seizures may be provoked by exercise have been postulated. These include hyperventilation with resultant hypocarbia and alkalosis induced by exercise. Another possible mechanism which is postulated to cause exercise induced seizures is hypoglycemia. This usually causes seizures after exercise in diabetic patients. Other mechanisms which have been postulated for exercise triggered seizures include the physical and psychological stress of competitive sports and potential changes in anti-epileptic drug metabolism. Exercise is a complex behavior and involves not such the motor system and the motor cortex but also involves other domains such as attention, concentration, vigilance and presumably some limbic networks which mediate motivation, aggression and competitiveness. Hence it is possible that patients who have temporal or frontal lobe epilepsy may on rare occasions have seizures triggered by exercise.

 

There is some limited evidence that exercise may in fact be protective and have physical, physiological and psychological benefits in patients with epilepsy. Electroencephalographic studies have shown that inter-ictal epileptiform discharges either remain unchanged or may decrease during exercise so there is some hint that exercise may actually raise the seizure threshold. Regular exercise also influences neuronal and hippocampal plasticity by upregulation of neurotropic factors. There is further evidence to suggest that regular physical exercise can improve the quality of life, reduce anxiety and depression and improve seizure control in patients with chronic epilepsy.

 

 

 

 

 

 

 

 

What sports are off limits for people with epilepsy?

 

No sport is completely off limit for a patient with epilepsy. Key though is proper supervision to reduce the potential for injury. There are some sports such as skydiving, automobile racing, swimming in the open seas and horseback riding which should be avoided by patients with epilepsy. Other sports can be enjoyed by patients with epilepsy but one should remember that they all have the potential to result in bodily harm if seizures occur when the patient is not supervised or if he is not wearing protective head and body gear.

 

 

Concussion and seizures (post traumatic epilepsy): what is the link?

 

The link between concussion (closed head trauma) and seizures has been and continues to be closely looked at. The fear of concussions (minor head trauma) making seizures worse is the prime reason why people with epilepsy are discouraged from some sports such as tackle football, ice-hockey, boxing, mixed martial arts and wrestling. The human skull is quite resilient and the closed head trauma has to be significant for it to result in seizures. Usually a concussion which results in prolonged loss of consciousness (some authors say more than 30 minutes) is graded as a significant head trauma. Minor bumps and bruises to the head do not cause seizures, do not increase the risk of future seizures and more importantly do not make chronic epilepsy worse. Seizures may occur immediately following a severe closed head trauma. Immediate post traumatic seizures by definition occur within 24 hours of the injury. They have also been referred to as impact seizures. Early post traumatic epilepsy refers to seizures which occur about a week to 6 months after the injury. Seizures may occur as far out at 2 to 5 years after head trauma (late post traumatic epilepsy). Factors which increase the risk of post traumatic seizures/ epilepsy include severity of trauma, prolonged loss of consciousness (more than 24 hours), penetrating head injury, intra or extraaxial hemorrhage, depressed skull fracture and early post traumatic seizures.

Counseling patients

 

Patients with epilepsy should be encouraged to exercise and take part in sports. My personal feeling is that no sport should be off limits to them with the exception of maybe sky-diving, river rafting and boxing. The goal should be exercising and playing sports safely. Walking, running, cycling and yoga are great exercises which can be indulged in with little to no risks. I advise all my patients with epilepsy (especially those with poorly controlled epilepsy) to wear a Medic Alert bracelet or carry a card in their wallet. This is of immense help were a seizure to occur in the field (as for example when a patient is jogging or cycling and is not in the immediate vicinity of his or her home). Low risk recreational sports such as walking or running usually do not need a one is to one supervision if seizures are well controlled by history. Team sports such as volleyball, basketball, baseball and softball are popular sports which carry a low risk of injury. For cycling I advise my patients to wear a helmet and have their bikes fitted with lights and reflectors. I also advise them to keep off from the busy city streets. “you do not want to have a seizure at the wrong place and at the wrong time”. Swimming is a great way to keep fit and also to meet and make friends. I feel many patients with epilepsy are discouraged from swimming due to an irrational fear of caregivers and physicians of drowning. I advise my patients not to swim alone. Most of the city pools have life guards and a polite request to them to keep a watch out goes a long way in reassuring both the patient and the caregivers. Swimming in the open seas is more risky. I advise my patients to swim close to the beach under the watchful eyes of a life guard. Also having a buddy around helps, preferably someone strong enough to pull the patient out of the water if a seizure was to occur. The option of wearing a life jacket is under utilized.

 

Final thoughts (a patient’s perspective)

 

These are the thoughts of a young patient of mine:

 

“I have always been a very active person and love playing sports such as Tennis, Yoga, Running etc, and I always try to pursue my dreams and not let things get in the way, but being epileptic, it is sometime hard to not worry about things happening. Whenever I play sports I get hot easily (face turns purple) and in the back of my head I find myself always hoping that nothing happens that would cause me to have a seizure. I ran my first half marathon two years ago, and in the back of my head there is always the thought of something happening, so I started to motivate myself by saying “I can do this, you will be fine.” My father taught me when I was younger that I can choose to let it hold me back or make the most of life! Many people consider epilepsy a disability, but I try not to because I don’t let it hold me back.”

 

 

Nitin K Sethi, MD, MBBS, FAAN Assistant Professor of Neurology New York-Presbyterian Hospital Weill Cornell Medical Center

Insomnia-what we know and how to treat it

Insomnia-what we know and how to treat it

 

 

Nitin K Sethi, MD, MBBS, DNB (Int Med), FAAN

 

 

 

 

In this blog post I shall address insomnia. Insomnia is a rather common medical problem for which patients consult doctors and sleep physicians. Broadly speaking insomnia can be of two types: sleep onset insomnia (the person finds it hard to fall asleep. Normal sleep latency is usually around 10 to 15 mins. Patients with sleep onset insomnia lie in bed sometimes for hours but sleep eludes them) and sleep maintenance insomnia (normally humans should be able to maintain sleep for 6 to 8 hours, though some of us are short sleepers and others long sleepers. People with sleep maintenance insomnia are unable to maintain sleep waking up multiple times during the night and struggling to fall back asleep again). One of the most common type of insomnia is psychophysiological insomnia and this is what I shall address in detail.

 

Psychophysiological insomnia (PPI)-these are people who cannot “shut their brains down at night”. At night when they settle down to sleep, their mind races (they are thinking about various things-work, personal issues and so forth). As a result they cannot sleep and keep looking at the clock. Over time this behavior gets reinforced to the extent that sleep itself becomes an anxiety provoking stimulus. Meaning they are anxious at night. Most of the people who suffer from PPI also suffer from anxiety and depressive disorders.

 

How to diagnose psychophysiological insomnia-usually a good history is sufficient in helping to diagnose PPI. Do you think a lot when you are lying in bed? Do you find it difficult to shut/power your brain down? Do you feel anxious in your own bed? Do you suffer from anxiety disorder and depression? Are your insomnia problems chronic (lasted more than 6 months)? Were other causes of insomnia ruled out such as insomnia due to medical problems (congestive heart failure, COPD, nocturnal asthma), insomnia due to certain medications and so forth. Your doctor may order a sleep study. The sleep study is done to rule out obstructive sleep apnea as a cause of disturbed sleep. It also helps your doctor get an idea of your sleep architecture (how much time you spent in different stages of sleep-light Vs. deep Vs. REM). Your doctor may also ask you to maintain a sleep diary. This is a record of your sleeping habits for a period of usually 2 weeks and helps the doctor better understand your sleep quality and hygiene.

 

Treatment of psychophysiological insomnia-treatment of PPI can be extremely challenging for the physician and frustrating for the patient. There is no good treatment but let us talk about what is out there, what helps and what does not.

  1. Cognitive behavioral therapy (CBT-I) for insomnia is probably what works the best. CBT-I is usually administered by a psychologist and involves several sessions spread over weeks. The therapist attempts to figure out what thoughts keep the patient awake at night and addresses them. Instructions to help structure sleep and wake up times is an important component of CBT-I. CBT-I takes time to act but in the long term is probably equally if not more effective and safer for treatment of PPI than sleeping pills (sedative-hypnotic medications).
  2. Sedative-hypnotic medications (sleeping pills)-there are numerous on the market both over the counter (OTC) ones such as Benadryl, Zzz Quil (to name a few) and prescription ones such as Ambien, Lunesta, Sonata, Belsomra, clonazepam, diazepam, Xanax (to name a few). These medications do work and they work by increasing chemicals in brain that promote sleep namely GABA. Belsomra is a new drug which was launched recently. As compared to other drugs, it works by decreasing chemicals in the brain that keep us awake. Sleeping pills have the advantage that they work quickly but they have 2 big problems. Regular/nightly use of sleeping pills makes the patient dependent upon them. The other problem with regular/nightly use is tolerance (example initially 5 mg of Ambien works great but then it stops acting and the patient needs a higher dose of Ambien say 10 mg to achieve sleep).
  3. Sedating anxiolytic-antidepressant medications: examples include Trazodone, Doxepin and amitriptyline. These medications are taking on a nightly basis and the goal is to address PPI by treating the patient’s anxiety disorder. The sedating qualities of these medications initially is useful in helping patient’s fall asleep.
  4. Non-sedating anxiolytic-antidepressants medications: examples include Paxil and Celexa to name a few. Goal here is to treat the patient’s anxiety/depression. Since these are not sedating, they are administered during the day.
  5. Entraining the circadian rhythm: one important thing which is ignored when insomnia is treated is entrainment of the patient’s circadian rhythm. In the hypothalamus of the brain there are a group of brain cells (called suprachiasmatic nucleus) which helps to maintain circadian rhythm (sleep wake cycle). Many patients with insomnia have poorly entrained circadian rhythm with no regular sleep-wake times. They are frequently night owls and so when they get into bed early say around 11 pm, they are unable to fall asleep since the sleep drive is not there (their brain may be geared to fall asleep around 1 pm). So it is important to structure sleep with the establishment of regular sleep wake times. The circadian rhythm is entrained by light and exercise. Patients should be encouraged to expose themselves to sunlight in the morning after waking up. Exercise in the morning is also helpful.
  6. Steps to improve sleep hygiene: Use the bed only for sleeping or sex. Do not carry your work to bed. Do not use laptops, smart phone while in bed. Your brain should associate your bed with sleep and not work. Half an hour before bedtime, room lights should be dimmed. TV, computers and smart phones should be tuned off and one should engage in activities that relax and calm the brain. This may be reading a book, meditating or even watching TV if that relaxes you. A hot shower before bedtime, drinking hot decaffeinated tea or warm milk increases the core body temperature and promotes good sleep. Deep slow breathing exercises are also very helpful (you can find some of these on the Internet).

I hope you find this blog posting on sleep and insomnia helpful. Sweet dreams everyone!